Antiepileptic Drugs Pregabalin Raw Powder CAS: 148553-50-8

Antiepileptic Drugs Pregabalin Raw Powder CAS: 148553-50-8

Description:

Pregabalin, marketed under the brand name Lyrica among others, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder.Its use for epilepsy is as an add-on therapy for partial seizures with or without secondary generalization in adults.Some off-label uses of pregabalin include restless leg syndrome,prevention of migraines,anxiety disorders,and alcohol withdrawal.When used before surgery it does not appear to affect pain after surgery but may decrease the use of opioids.

Common side effects include: sleepiness, confusion, trouble with memory, poor motor coordination, dry mouth, problem with vision, and weight gain.Potentially serious side effects include angioedema, drug misuse, and an increased suicide risk.When pregabalin is taken at high doses over a long period of time, addiction may occur, but if taken at usual doses the risk of addiction is low.Pregabalin is a gabapentinoid and acts by inhibiting certain calcium channels.

Parke-Davis developed pregabalin as a successor to gabapentin and was brought to market by Pfizer after the company acquired Warner-Lambert.There is to be no generic version available in the United States until 2018.A generic version is available in Canada, the United Kingdom, Australia and Germany. In the US it costs about 300-400 USD per month.Pregabalin is a Schedule V controlled substance under the Controlled Substances Act of 1970 (CSA).

Basic information:

Chemical name: Pregabalin
MF: C8H17NO2
MW: 159.23
CAS: 148553-50-8
Appearance: White powder
Purity: over 99%

COA:
 
What is Pregabalin and what is it used for?

Pregabalin is used to treat some types of persistent pain. It is especially good for nerve pain, such as burning, shooting or stabbing pain. Pregabalin belongs to a group of medicines called anticonvulsants, which are also used to treat epilepsy.

Pregabalin works by changing the way that nerves send messages to your brain. If the messages are reduced, then the pain will be reduced.

How do I take Pregabalin?

You may need to take this medicine for a few weeks before you feel any change in your pain.  Normally, the starting dose is small and may be taken between one and three times a day, but the dose will be gradually increased. Instructions will be given to you on what dose to start taking and how to increase the dose. The table below will help to guide you.  If you are taking antacid medication it is best to wait for two hours after taking it before taking gabapentin.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of pregabalin in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pregabalin in the elderly. However, elderly patients are more likely to have unwanted effects (eg, dizziness, blurred vision, confusion, or clumsiness), and age-related kidney problems, which may require an adjustment in the dose for patients receiving pregabalin.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

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